Innovative Approaches for Treating Complex Diseases
We are advancing Cellular Nanoparticle programs that address critical unmet needs.
Candidate
Preclinical
Phase 1
Phase 2
Inflammation
IBD
CTI-121
Inflammation
Arthritis
Undisclosed
Cytokine Storm
Cytokine Storm is a life-threatening systemic inflammatory condition involving elevated levels of circulating cytokines and immune cell hyperactivation. The body loses control of its production of cytokines and the immune system produces excessive amounts of cytokines, leading to symptoms such as high fevers and low blood pressures and multiple organ failures.
Common triggers of Cytokine Storm include:
- Bacterial or viral infections (e.g., MRSA, COVID-19) – Sepsis
- Immunotherapy (e.g., CAR-T therapy, checkpoint inhibitor) – Cytokine Release Syndrome (CRS)
- Autoimmune conditions (e.g., Lupus, Still’s Disease, Systemic Juvenile Idiopathic Arthritis (sJIA))
- Monogenic disorders (e.g., Cystic Fibrosis)
- Graft-versus-host disease (GvHD)
Many different inflammatory cytokines (e.g., IL-1, IL-6, IL-8, IL-12, IL-18, TNF-α, IFN-α, IFN-β, IFN-γ, MCP-1) are involved in cytokine storm, making therapeutics that target one or a few of these cytokines not very effective. Steroids that can lower cytokine production do so by suppressing the whole immune system, leading to lower efficacy for immunotherapy, potential infections, and long-term side effects.
Cellics’ CNP™ Technology is uniquely positioned to treat complicated multifactorial diseases such as Cytokine Storm since Cellular Nanoparticles created with either wild-type or engineered cell membranes have multiple receptors to neutralize many different types of inflammatory cytokines. Cellular Nanoparticles can cool down out-of-control immune systems without weakening the whole immune system and thus have a particular advantage for treating Cytokine Storm caused by various triggers.
Autoimmune Diseases
Autoimmune Diseases are a type of disease in which a person’s immune system mistakenly attacks the body’s own healthy cells, tissues, and organs. There are more than 100 autoimmune diseases affecting 50 million Americans every day. Approximately 75% of those affected are women. People with autoimmune diseases face common flare-ups and sometimes even life-threatening symptoms. Many of these autoimmune diseases have very few treatment options or no cure at all.
Innovatively engineering nanoparticles to mimic natural cells, Cellics’ Cellular Nanoparticle (CNP™) Technology can protect the body from the attacks of overreacted immune cells and restore the balance of the immune system.
Pipeline Expansion
The Cellular Nanoparticle (CNP™) Technology can be applied to biodefense as countermeasures as well.
We Strive to Advance Transformative Therapies for Diseases with High Unmet Medical Needs
Cellics seeks to apply its innovative and versatile CNP™ Technology to better treat and prevent serious diseases with high unmet medical needs.